Thermo Fisher Scientific Perforin Polyclonal Antibody
Thermo Fisher Scientific의 Perforin Polyclonal Antibody는 인간 Perforin 단백질을 인식하는 토끼 다클론 항체입니다. Western blot에 최적화되어 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 세포독성 림프구 연구 및 면역학 연구용으로 적합합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Perforin Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 9–214 of Perforin 1 (Uniprot ID: P14222) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.37 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11152526 |
Product Specific Information
- Recommended positive control: HepG2
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
Perforin is one of the major cytolytic proteins of cytolytic granules. It acts as a cytolytic mediator stored and released by cytoplasmic granules and plays a critical role in immune defense against tumors and viral infections mediated by cytotoxic lymphocytes.
Perforin is a 555 amino acid protein with a 21 amino acid signal peptide and has a molecular weight of 70–75 kDa. It forms transmembrane pores similar to complement component C9, showing structural homology.
Perforin expression is restricted to killer cell lines, not helper T cells or other tumor cells. It is a key effector molecule for T-cell and NK-cell-mediated cytolysis.
Mutations in the perforin gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.