Thermo Fisher Scientific Perforin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive control: HepG2
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

Perforin is one of the major cytolytic proteins of cytolytic granules. It acts as a cytolytic mediator stored and released by cytoplasmic granules and plays a critical role in immune defense against tumors and viral infections mediated by cytotoxic lymphocytes.
Perforin is a 555 amino acid protein with a 21 amino acid signal peptide and has a molecular weight of 70–75 kDa. It forms transmembrane pores similar to complement component C9, showing structural homology.
Perforin expression is restricted to killer cell lines, not helper T cells or other tumor cells. It is a key effector molecule for T-cell and NK-cell-mediated cytolysis.
Mutations in the perforin gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.