Thermo Fisher Scientific GLRB Polyclonal Antibody

Thermo Fisher Scientific GLRB Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Immunogen sequence:
  KEKSSKKGKG KKKQYLCPSQ QSAEDLARVP ANSTSNILNR LLVSYDPRIR PNFKGIPVDV VVNIFINSFG SIQETTMDYR VNIFLRQKWN DPRLKLPSDF RGSDALTVDP TMYKCLWKPD LFFANEKSAN FHDVTQENIL LFIFRDGDVL VSMRLSITLS CPLDLTLFPM DTQRCKMQLE SFGYTTDDLR FIWQSGDPVQ LEKIALPQFD IKKEDIEYGN CTKYYKGTGY YTCVEVIFTL RRQ
• Positive Samples: U-251MG, H460, HT-1080, THP-1, Mouse brain, Mouse liver, Mouse eye, Rat brain, Rat liver
• Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse

Target Information

In the central nervous system (CNS), glycine-mediated inhibitory neurotransmission is essential to voluntary motor control and reflex responses. Glycine binds to glycine receptors (GlyR) in the postsynaptic neuronal membranes. GlyR, gamma-aminobutyric acid, serotonin, and acetylcholine comprise an evolutionarily conserved superfamily of ligand-gated ion channels.
The pentameric subunit structure of GlyR consists of two types of glycosylated membrane proteins (alpha1–alpha4 and beta) and an associated peripheral membrane protein, forming a chloride-selective ion channel. In humans, the composition of the pentamer changes from alpha2 subunits in the fetal CNS to alpha1 and beta subunits in the adult CNS.
Fast potentiation of GlyR by intracellular Ca²⁺ in the brainstem and midbrain indicates an important role for Ca²⁺ in modulation of glycinergic synapses.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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