Thermo Fisher Scientific CD209b (SIGN-R1) Monoclonal Antibody (eBio22D1 (22D1)), eBioscience
마우스 SIGNR1(CD209b)을 인식하는 eBio22D1 단클론 항체로, Flow Cytometry, IHC, ELISA 등에 적합합니다. 비접합 형태로 제공되며 0.5 mg/mL 농도의 액상 제품입니다. 높은 순도(>90%)와 낮은 응집도(<10%)를 보장합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | 5 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent | - |
| Immunocytochemistry (ICC/IF) | - | 2 publications |
| Flow Cytometry (Flow) | 1 µg/test | 5 publications |
| ELISA | Assay-Dependent | - |
| Immunoprecipitation (IP) | Assay-Dependent | - |
| Functional Assay | Assay-Dependent | 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Published Species | Mouse |
| Host / Isotype | Armenian hamster / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio22D1 (22D1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_795886 |
Additional Formats:
- Alexa Fluor 488 (Product #53-2093-82)
- APC (Product #17-2093-82)
- Functional Grade (Product #16-2093-82)
- Request Custom Conjugation
Product Specific Information
Description:
The eBio22D1 monoclonal antibody reacts with mouse SIGNR1 (CD209b). SIGNR1 is a type II transmembrane C-type lectin, identified as a mouse homologue of human DC-SIGN. It is highly expressed in splenic marginal zone and lymph node medullary macrophages, functioning in uptake of dextran polysaccharides including the capsular polysaccharide of Streptococcus pneumoniae. SIGNR1 associates with TLR4/MD2 and may play a role in LPS recognition. SIGNR1-deficient mice exhibit defects in complement C3 catabolism, and SIGNR1 binds directly to complement C1q to form a non-conventional C3 convertase.
The eBio22D1 antibody does not cross-react with SIGNR2, SIGNR3, or SIGNR4.
Applications Reported:
This antibody has been reported for use in:
- Flow cytometric analysis
- Immunoprecipitation
- Immunohistology staining of frozen tissue sections
- ELISA
Functional assays should use the Functional Grade purified form (Product #16-2093-82).
Applications Tested:
Tested by flow cytometric analysis of mouse splenocytes. Recommended ≤1 µg per test (100 µL final volume). Cell count may vary from 10⁵ to 10⁸ cells/test. Antibody titration is advised for optimal assay performance.
Purity: >90% (SDS-PAGE)
Aggregation: <10% (HPLC)
Filtration: 0.2 µm post-manufacturing filtered
Target Information
SIGNR1 is a type II transmembrane C-type lectin expressed in splenic marginal zone and lymph node medullary macrophages. It uptakes dextran polysaccharides and interacts with TLR4/MD2, contributing to LPS recognition. SIGNR1-deficient mice show impaired complement C3 catabolism, and SIGNR1 binds directly to complement C1q to form a non-conventional C3 convertase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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