Thermo Fisher Scientific EXOSC10 Polyclonal Antibody
Rabbit polyclonal antibody against human EXOSC10, validated for WB and IP. Targets residues 835–885 of Exosome Component 10. Supplied as liquid, 1 mg/mL, stored at 4°C. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 835 to 885 of human Exosome Component 10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a nuclear/nucleolar particle termed PM-Scl. Exosome component 10 (EXOSC10), also named autoantigen PM/Scl-2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl patients.
EXOSC10 is strongly enriched in the nucleolus, with a small amount found in the cytoplasm, supporting the existence of a nucleolar RNA exosome complex form.
As a putative catalytic component of the RNA exosome complex with 3′→5′ exoribonuclease activity, EXOSC10 participates in various RNA processing and degradation events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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