Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI4F10), TrueMAB

Applications and Tested Dilutions

Product Specifications

Target Information

Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by peptides bound to MHC molecules on antigen-presenting cells (APCs). T-cell activation is self-limited as activated T cells express receptors such as PD-1 (PDCD-1) that mediate inhibitory signals from APCs. PD-1 binds to ligands PDL-1 and PDL-2, generating inhibitory signals that suppress immune activation in the absence of danger signals (e.g., LPS or bacterial molecules). PD-1 deficiency can lead to hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.