Thermo Fisher Scientific Caveolin 1 Polyclonal Antibody
Rabbit polyclonal antibody targeting Caveolin-1, reactive with human and non-human primates. Suitable for IHC(P) applications with 1:250 dilution. Purified by antigen affinity chromatography and supplied as liquid form (1 mg/mL) in PBS with sodium azid...
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Applications
- Immunohistochemistry (Paraffin) [IHC(P)]
- Tested Dilution: 1:250
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Non-human primate, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from N-terminus of human CAV1 / Caveolin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550153 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Chimpanzee, Gorilla, Gibbon, Baboon, Monkey, Marmoset (100%); Orangutan, Guinea pig (94%); Mouse, Rat, Dog, Rabbit, Horse, Turkey, Chicken (88%); Galago, Ferret, Sheep, Cat, Bat, Bovine, Panda, Pig, Opossum, Armadillo, Lizard (81%).
For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
Caveolin-1 (CAV1) is a scaffolding protein within caveolar membranes that interacts directly with G-protein alpha subunits, regulating their activity. It plays a role in T-cell receptor (TCR)-mediated activation and can bind DPP4, inducing T-cell proliferation and NF-kappa-B activation.
Mutations in the CAV1 gene are associated with congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, and partial lipodystrophy/congenital cataracts and neurodegeneration syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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