Thermo Fisher Scientific Caveolin 1 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) [IHC(P)]
  • Tested Dilution: 1:250

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Chimpanzee, Gorilla, Gibbon, Baboon, Monkey, Marmoset (100%); Orangutan, Guinea pig (94%); Mouse, Rat, Dog, Rabbit, Horse, Turkey, Chicken (88%); Galago, Ferret, Sheep, Cat, Bat, Bovine, Panda, Pig, Opossum, Armadillo, Lizard (81%).

For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

Caveolin-1 (CAV1) is a scaffolding protein within caveolar membranes that interacts directly with G-protein alpha subunits, regulating their activity. It plays a role in T-cell receptor (TCR)-mediated activation and can bind DPP4, inducing T-cell proliferation and NF-kappa-B activation.
Mutations in the CAV1 gene are associated with congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, and partial lipodystrophy/congenital cataracts and neurodegeneration syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.