Thermo Fisher Scientific Caveolin 1 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) [IHC (P)]

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Baboon, Monkey, Galago, Marmoset, Mouse, Rat, Ferret, Sheep, Bovine, Dog, Cat, Bat, Horse, Rabbit, Pig, Guinea pig (100%); Elephant, Armadillo (93%).

For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

Caveolin-1 (CAV1) is a scaffolding protein within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in co-stimulatory signaling essential for T-cell receptor (TCR)-mediated T-cell activation. It can bind with DPP4 and induce T-cell proliferation and NF-kappa-B activation in a TCR/CD3-dependent manner.
Mutations in the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)