Thermo Fisher Scientific SLC8A1 Polyclonal Antibody
SLC8A1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC(P) 실험에 적합합니다. 인간, 생쥐, 랫드에 반응하며, 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SLC8A1 (Accession P32418), corresponding to amino acid residues Y261–E311 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2853487 |
Product Specific Information
Antibody detects endogenous levels of total SLC8A1.
Target Information
Ca²⁺ plays a critical role in intracellular signaling, and regulation of calcium balance is essential for maintaining this function. The plasma membrane Na⁺/Ca²⁺ exchangers (NaCX) mediate Na⁺-dependent Ca²⁺ efflux in various cell types. NaCX can move Ca²⁺ either into or out of cells, depending on ionic gradients across the membrane.
In mammals, at least five distinct genes encode these exchangers: three NaCX (NaCX-1, NaCX-2, NaCX-3) and two in the NaCKX family (NaCKX-1, NaCKX-2).
NaCX-1 is highly expressed in the heart, where it plays a major role in excitation–contraction coupling (Matsuoka et al., 1993). NACX-1 may also serve as a target for protecting the heart and brain from ischemia and reperfusion injury (Hagihara et al., 2005; Bano et al., 2005; Choi, 2005).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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