Thermo Fisher Scientific SLC8A1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total SLC8A1.

Target Information

Ca²⁺ plays a critical role in intracellular signaling, and regulation of calcium balance is essential for maintaining this function. The plasma membrane Na⁺/Ca²⁺ exchangers (NaCX) mediate Na⁺-dependent Ca²⁺ efflux in various cell types. NaCX can move Ca²⁺ either into or out of cells, depending on ionic gradients across the membrane.
In mammals, at least five distinct genes encode these exchangers: three NaCX (NaCX-1, NaCX-2, NaCX-3) and two in the NaCKX family (NaCKX-1, NaCKX-2).
NaCX-1 is highly expressed in the heart, where it plays a major role in excitation–contraction coupling (Matsuoka et al., 1993). NACX-1 may also serve as a target for protecting the heart and brain from ischemia and reperfusion injury (Hagihara et al., 2005; Bano et al., 2005; Choi, 2005).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.