Thermo Fisher Scientific NOV Recombinant Rabbit Monoclonal Antibody (130)

Applications

ELISA (ELISA)

• Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal clones for production.
Advantages include:

• Enhanced specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broad immunoreactivity due to the rabbit immune repertoire

This antibody specifically recognizes Human CCN3/NOV/IGFBP9.

Target Information

NOV is a member of the CCN family of secreted, cysteine-rich regulatory proteins. The full-length NOV protein contains four structural domains with distinct biological activities. Elevated NOV expression is associated with certain tumors such as Wilms’ tumor and most nephroblastomas, while decreased expression correlates with increased tumorigenicity in other cancers.
NOV also promotes cell adhesion and migration by interacting with integrins, heparin sulfate proteoglycans, and fibulin 1C, and exhibits proangiogenic activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.