Thermo Fisher Scientific NOV Monoclonal Antibody (6F1C9C4)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:1,000–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination.
This antibody has specificity for Human NOV/CCN3.

Target Information

NOV is a member of the CCN family of secreted, cysteine-rich regulatory proteins. The full-length NOV protein contains four structural domains that confer distinct and sometimes opposing biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm’s tumor and most nephroblastomas. In other tumor types and certain cancer cell lines, increased tumorigenicity and proliferation correlate with decreased NOV expression. Additionally, NOV induces cell adhesion and migration by signaling through specific cell-surface integrins and by binding to heparin sulfate proteoglycans and fibulin 1C. NOV has also been reported to exert proangiogenic activities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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