Thermo Fisher Scientific APOBEC3C Polyclonal Antibody
Human 및 Mouse 시료에 반응하는 Rabbit Polyclonal APOBEC3C 항체. Western blot 및 IHC(P)에서 사용 가능하며, 고순도의 Affinity chromatography로 정제됨. PBS/glycerol buffer에 보관되며, -20°C에서 안정적으로 저장 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human APOBEC3C (Accession Q9NRW3), corresponding to amino acid residues N159–Q190 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852707 |
Product Specific Information
Antibody detects endogenous levels of total APOBEC3C.
Target Information
APOBEC (apolipoprotein B mRNA editing enzyme, catalytic) proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA. The seven APOBEC3 genes or pseudogenes are located in a cluster on chromosome 22, likely resulting from gene duplication.
Like APOBEC3G, APOBEC3F deaminates deoxycytosine to deoxyuracil in the minus strand of HIV-1 DNA, causing G-to-A hypermutation in the plus strand. APOBEC3G and APOBEC3F thus contribute to innate immunity against retroviruses and genetic variation in many viruses.
HIV-1 Vif protein counteracts APOBEC3G and APOBEC3F by impairing translation and promoting proteasomal degradation. Interestingly, mouse APOBEC3G/F resist HIV-1 Vif, effectively inhibiting wild-type HIV-1 replication, whereas human APOBEC3G/F inhibit only Vif-deficient HIV-1. Modulating APOBEC3G/F activity or blocking their interaction with Vif could have therapeutic potential.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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