Thermo Fisher Scientific Lamin B Receptor Polyclonal Antibody
Rabbit polyclonal antibody recognizing human Lamin B Receptor. Validated for IHC (Paraffin). Purified by antigen affinity chromatography, supplied in PBS with 40% glycerol. Suitable for research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Lamin B Receptor. Recombinant protein control fragment (Product # RP-99796) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2643256 |
Product Specific Information
Immunogen sequence:
MPSRKFADGE VVRGRWPGSS LYYEVEILSH DSTSQLYTVK YKDGTELELK ENDIKPLTSF RQRKGGSTSS S
Sequence identity (orthologs):
- Mouse: 87%
- Rat: 89%
Target Information
The Lamin B Receptor protein belongs to the ERG4/ERG24 family and is localized in the inner membrane of the nuclear envelope. It anchors the lamina and heterochromatin to the membrane and may mediate interactions between chromatin and lamin B. Mutations in this gene are associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing at this locus produces two transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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