Thermo Fisher Scientific Rat SCF, Animal-Free Recombinant Protein, PeproTech

Applications

• Functional Assay (Functional)

Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

Recombinant Rat SCF is an 18.4 kDa polypeptide containing 165 amino acid residues, corresponding to the sequence of the secreted soluble form of SCF.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.

Target Information

Stem Cell Factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways.
Binding of SCF to the c-Kit receptor induces receptor homodimerization and activates signaling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase.
SCF expression promotes mast cell survival and the release of histamine, pro-inflammatory cytokines, and chemokines.
Inhibition of the SCF/c-Kit pathway reduces histamine levels, mast cell and eosinophil infiltration, IL-4 production, and airway hyperresponsiveness, suggesting its potential as a therapeutic target in inflammatory diseases such as asthma.
At least two isoforms of SCF are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.