Thermo Fisher Scientific Rat SCF, Animal-Free Recombinant Protein, PeproTech
Rat SCF 재조합 단백질로, E. coli에서 발현된 18.4 kDa 동물유래 성분 없는 단백질. 인간 TF-1 세포 증식을 유도하는 생물학적 활성 확인. ≥98% 순도, <0.1 EU/µg 엔도톡신 수준. 줄기세포 및 면역학 연구용.
- 카탈로그번호
- AF-400-22-xxx (4개 옵션)
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
4개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Rat SCF, Animal-Free Recombinant Protein, PeproTech
Applications
- Functional Assay (Functional)
Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Rat |
| Expression System | E. coli |
| Amino Acid Sequence | MQEICRNPVT DNVKDITKLV ANLPNDYMIT LNYVAGMDVL PSHCWLRDMV THLSVSLTTL LDKFSNISEG LSNYSIIDKL GKIVDDLVAC MEENAPKNVK ESLKKPETRN FTPEEFFSIF NRSIDAFKDF MVASDTSDCV LSSTLGPEKD SRVSVTKPFM LPPVA |
| Molecular Weight | 18.4 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | < 0.1 EU/µg |
| Activity | Determined by dose-dependent stimulation of human TF-1 cell proliferation (ED50: 20–40 ng/ml) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Rat SCF is an 18.4 kDa polypeptide containing 165 amino acid residues, corresponding to the sequence of the secreted soluble form of SCF.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
Stem Cell Factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways.
Binding of SCF to the c-Kit receptor induces receptor homodimerization and activates signaling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase.
SCF expression promotes mast cell survival and the release of histamine, pro-inflammatory cytokines, and chemokines.
Inhibition of the SCF/c-Kit pathway reduces histamine levels, mast cell and eosinophil infiltration, IL-4 production, and airway hyperresponsiveness, suggesting its potential as a therapeutic target in inflammatory diseases such as asthma.
At least two isoforms of SCF are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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