Thermo Fisher Scientific Rat GM-CSF, Animal-Free Recombinant Protein, PeproTech
Rat GM-CSF 재조합 단백질로, E. coli 발현 시스템에서 생산된 고순도(≥98%) 단백질입니다. 마우스 FDC-P1 세포 증식을 자극하는 활성을 가지며, 엔도톡신 함량은 <0.1 EU/µg입니다. 동결건조 형태로 제공되며, -20°C에서 보관합니다.
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Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to related publications
Miscellaneous PubMed (Misc)
- Refer to related publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Rat |
| Published species | Mouse, Rat |
| Expression System | E. coli |
| Amino Acid Sequence | MAPTRSPNPV TRPWKHVDAI KEALSLLNDM RALENEKNED VDIISNEFSI QRPTCVQTRL KLYKQGLRGN LTKLNGALTM IASHYQTNCP PTPETDCEIE VTTFEDFIKN LKGFLFDIPF DCWKPVQK |
| Molecular Weight | 14.5 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | < 0.1 EU/µg |
| Activity | Stimulates proliferation of mouse FDC-P1 cells. Expected ED50 ≤ 0.01 ng/ml (≥ 1 x 10^8 units/mg) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Rat GM-CSF is a 14.5 kDa globular protein consisting of 128 amino acid residues.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
The GM-CSF gene encodes a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active protein form exists as a homodimer in the extracellular space.
This gene is located in a cluster of related genes at chromosome region 5q31, associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia.
Other genes in the cluster include interleukins 4, 5, and 13. The gene promotes tissue inflammation, and elevated cytokine levels have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome.
Mice lacking this gene or its receptor develop pulmonary alveolar proteinosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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