Thermo Fisher Scientific Integrin beta 3 Polyclonal Antibody
Integrin beta 3 (CD61) 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ELISA, IP 등 다양한 응용에 적합. 인간 및 비인간 영장류 반응성. 고순도 친화 크로마토그래피 정제. 안정한 액상 형태로 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 1–50 on human Integrin Beta 3 subunit protein (CD61, UniProt ID: P05106-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets, and their precursors. It plays a key role in platelet aggregation and functions as a receptor for fibrinogen, fibronectin, von Willebrand factor, and vitronectin.
CD61 (105 kDa) associates with either alpha IIb integrin (CD41) or alpha V integrin (CD51) at the cell surface. It is expressed on platelets and megakaryocytes (with CD41) and on endothelial cells, monocytes, and osteoclasts (with CD51).
CD61 participates in cell adhesion and cell-surface mediated signaling. Dysfunction of CD61 is associated with Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: INTGB3-101AP_CD61_Integrin_beta_3_P05106-1_Rabbit.svg, INTGB3-101AP_CD61_Integrin_beta_3_P05106-1_Rabbit_PDP.jpeg)
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