Thermo Fisher Scientific CD200R Recombinant Rabbit Monoclonal Antibody (019)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Mouse CD200R1.

Target Information

CD200R (OX2R) is a receptor for the OX-2 membrane glycoprotein, and both receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains.
CD200R is restricted to the surfaces of myeloid lineage cells, and the receptor-substrate interaction may function as a myeloid downregulatory signal.

In mouse, CD200R is expressed primarily by peripheral blood monocytes and neutrophils, but also by other leukocytes including T-lymphocytes and mast cells.
Further studies suggest that CD200R may control myeloid function in a tissue-specific manner.
Alternative splicing of CD200R results in multiple transcript variants. Diseases associated with CD200R dysfunction include primary hypertrophic osteoarthropathy.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.