Thermo Fisher Scientific DC-SIGN Recombinant Rabbit Monoclonal Antibody (059)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:1,000–1:10,000

Product Specifications

Additional Formats

• HRP
• Request custom conjugation

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire

This antibody has specificity for Human CD209/DC-SIGN.

Target Information

This gene encodes a transmembrane receptor known as DC-SIGN, expressed on dendritic cells and macrophages. It plays a key role in the innate immune system, recognizing a wide range of pathogens from parasites to viruses.

Protein features:

• Three domains: N-terminal transmembrane, tandem-repeat neck, and C-type lectin carbohydrate recognition domain
• Functions as both pathogen recognition and cell adhesion receptor
• Neck region enables homo-oligomerization for high avidity binding
• Variations in neck domain repeats affect ligand binding ability
• Closely related to L-SIGN (GeneID 10332) with differing ligand-binding properties and distribution
• Alternative splicing produces multiple variants

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.