Thermo Fisher Scientific Furin Polyclonal Antibody
Human Furin 단백질을 인식하는 Goat Polyclonal Antibody로, ICC/IF에 적합하며 10 µg/mL 농도로 사용됩니다. Peptide Immunogen 기반으로 제작되었으며, 0.5 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA5142411
- 판매단위
- pk
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-RTKRDVYQEPTDP (aa 104–116) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933059 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
Furin is a membrane-associated, calcium-dependent serine protease belonging to the subtilisin-like prohormone convertase (PC) family. These enzymes cleave most prohormones and neuropeptide precursors, as well as various cellular, viral, and bacterial proteins transported via the constitutive secretory pathway.
Furin and other PCs share structural features including:
- An N-terminal proregion (~10 kDa)
- A conserved catalytic domain (~55 kDa)
- A variable C-terminal domain
Furin becomes catalytically active after proregion cleavage and is the only PC with a transmembrane domain. Cleavage occurs at the carboxyl terminus of the consensus sequence RX(K/R)R. The acidic sequence C771PSDSEEDEG780 localizes furin to the trans-Golgi network, and phosphorylation within this region affects intracellular routing. The Y759KGL762 motif mediates internalization from the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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