Thermo Fisher Scientific MKL2 Polyclonal Antibody
Human 및 Mouse에서 MKL2 단백질을 검출하는 Rabbit Polyclonal Antibody. Western blot에 적합하며, Affinity chromatography로 정제됨. PBS/glycerol buffer에 보관하며 -20°C에서 안정적. 연구용으로만 사용 가능.
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Thermo Fisher Scientific MKL2 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:1,000–1:3,000
Publications: - References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MKL2 (Accession Q9ULH7), corresponding to amino acid residues A605–S655 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852714 |
Product Specific Information
Antibody detects endogenous levels of total MKL2.
Target Information
Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence mediating the transient response of many cellular genes to growth stimulation.
SRF regulates the transient response of several muscle genes in response to growth factors and recruits accessory myogenic factors to activate these muscle genes.
SRF is required for vertebrate mesoderm formation, leading to the origin of the cardiovascular system.
Myocardin, in association with SRF in cardiac muscle cells, activates cardiac muscle promoters.
Myocardin-related transcription factors A and B (MRTF-A and MRTF-B) interact with SRF and act as stimulators for its transcriptional activity.
MRTF-B is crucial for skeletal myogenic differentiation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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