Thermo Fisher Scientific rpL7a/SURF3 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections
• Based on 100% sequence identity, this antibody is predicted to react with Rat, Chicken, and Bovine

Target Information

Cytoplasmic ribosomes, which catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. These subunits are composed of 4 RNA species and approximately 80 distinct proteins.
The rpL7a gene encodes a component of the 60S subunit and belongs to the L7AE family of ribosomal proteins. It interacts with nuclear hormone receptors, including the thyroid hormone receptor, inhibiting their DNA binding activity.
This gene is part of the surfeit gene cluster, co-transcribed with small nucleolar RNA genes (U24, U36a, U36b, and U36c). It can rearrange with the trk proto-oncogene to form the chimeric oncogene trk-2h, encoding an oncoprotein that fuses the N terminus of ribosomal protein L7a with the receptor tyrosine kinase domain of trk. Multiple processed pseudogenes of this gene are dispersed throughout the genome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.