Thermo Fisher Scientific Human TNF-RI (soluble) Recombinant Protein

Thermo Fisher Scientific Human TNF-RI (soluble) Recombinant Protein

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitution: Briefly centrifuge the vial before opening. Reconstitute sTNF-RI in 5 mM Tris, pH 8.0, to a concentration of 0.1–1.0 mg/mL. Further dilutions should be made in aqueous buffers supplemented with carrier protein (0.1–1.0% BSA).
• Storage: Lyophilized preparation is stable at 2–8°C, but should be kept at -20°C for long-term storage, preferably desiccated. Upon reconstitution, stable for up to one week at 2–8°C. For maximal stability, store aliquots at -20°C. Avoid repeated freeze/thaw cycles.

Target Information

TNFR1 (Tumor necrosis factor receptor 1) is a member of the TNF superfamily and a major receptor for TNF-α. It mediates cytokine signaling, positively regulates the NF-κB pathway and angiogenesis, and negatively regulates gene expression. The extracellular domain of TNFR1 can be released into circulation as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12. Interaction partners include BAG4/SODD, TRADD, and TRAF2, which regulate TNFR1-mediated signal transduction. Mutations in TNFR1 extracellular domains are associated with autosomal dominant periodic fever syndrome due to impaired receptor clearance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.