Thermo Fisher Scientific SKI Polyclonal Antibody
Human SKI 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 등 다양한 응용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 안정성을 제공. PBS/glycerol buffer에 보관되며 연구용으로 적합.
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Thermo Fisher Scientific SKI Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:25–1:100
Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide of human SKI |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.8 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2636701 |
Product Specific Information
The antibody detects endogenous levels of total SKI protein.
Target Information
TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN.
Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. Ski also binds to Smad proteins specific to bone morphogenic proteins (BMPs) and blocks BMP signaling in mammalian cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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