Thermo Fisher Scientific MRE11 Polyclonal Antibody
MRE11 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, IP 등 다양한 응용에 사용 가능. 인간 MRE11의 600–700 잔기 유래 펩타이드로 면역화됨. 마우스 및 랫트에서도 반응 예측. 액상 형태로 4°C 보관, 장기 보관 시 -20°C 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:250 |
| Immunocytochemistry (ICC/IF) | 1:200 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 600–700 of Human MRE11 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10983924 |
Product Specific Information
- Heat-mediated antigen retrieval is recommended prior to tissue staining.
- This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
MRE11 (double-strand break repair protein MRE11) is a component of the MRN complex.
This complex plays a central role in double-strand break repair, DNA recombination, maintenance of telomere integrity, and meiosis.
The complex possesses single-stranded endonuclease activity and double-strand-specific 3'-5' exonuclease activity provided by MRE11.
RAD50 is required to bind DNA ends and hold them in close proximity.
Mutations in the MRE11 gene could result in ataxia-telangiectasia-like disorder 1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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