Thermo Fisher Scientific HCG-beta Monoclonal Antibody (HCGb, 459)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed):
  Incubate antibody for 30 minutes at room temperature.
  Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

hCG beta is the beta chain of human chorionic gonadotropin (hCG), a 40 kDa glycoprotein hormone produced by trophoblastic cells of the placenta beginning 10–12 days after conception.
hCG consists of alpha and beta subunits that are non-covalently associated. The alpha subunit is similar to those found in pituitary hormones (FSH, LH, TSH), while the beta subunit confers biological specificity.

During early pregnancy, hCG maintains the corpus luteum, stimulating progesterone production to support the endometrium.
In non-pregnant individuals, hCG is present only in trace amounts but rises sharply during pregnancy.

Diseases associated with hCG dysfunction include gestational trophoblastic tumor and hydatidiform mole.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.