Thermo Fisher Scientific RUNX1T1 Polyclonal Antibody
RUNX1T1 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 인간에 반응하며 Rabbit IgG로 제조되었습니다. 액상 형태로 제공되며, -20°C 보관 시 안정적입니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.2–1 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human RUNX1T1 (aa 552–565) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2608092 |
Product Specific Information
Sequence homology:
- Cow: 100%
- Dog: 100%
- Guinea Pig: 93%
- Horse: 93%
- Human: 100%
- Mouse: 93%
- Pig: 100%
- Rabbit: 100%
- Rat: 86%
- Zebrafish: 93%
Target Information
RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities.
This translocation produces a chimeric gene made up of the 5′ region of the RUNX1 gene fused to the 3′ region of this gene.
The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.
Several transcript variants encoding multiple isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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