Thermo Fisher Scientific Phospho-Aurora B (Thr232) Polyclonal Antibody
Aurora B 단백질의 Thr232 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 1 mg/mL 액상 형태로 제공되며, -20°C에서 보관. 인간 시료에 검증됨.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | – |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human Aurora B around the phosphorylation site of Thr232 (R-K-TP-M-C) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2555156 |
Target Information
Aurora kinases associate with microtubules during chromosome movement and segregation. AURKB (Aurora B) localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. This complex functions in chromosome alignment and separation, histone modification, and cytokinesis.
The Chromosomal Passenger Complex (CPC) includes three non-enzymatic subunits—INCENP, survivin, and borealin—which determine the activity, localization, stability, and possibly substrate specificity of Aurora B. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and Aurora B. The quaternary CPC functions during chromosome alignment and cytokinesis, while the INCENP–AurB complex may be responsible for histone H3 modification.
Aurora B is overexpressed in several tumors, including primary breast and colon samples. Its expression appears linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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