Thermo Fisher Scientific AF10 Polyclonal Antibody
AF10 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC(P/F), Flow Cytometry 등 다양한 응용에 사용 가능. Human, Mouse, Rat에 반응하며, Protein A로 정제된 1 mg/mL 액상 형태. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:20–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human AF10/MLLT10 (amino acids 151–250) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Translocations affecting chromosome 11q23 involve many partner chromosome regions and occur in various leukemias. The 11q23 gene involved in the translocations is MLL. MLLT10 is the partner gene to MLL1 involved in t(10;11)(p12;q23) translocations.
In leukemia patients, this translocation fuses MLL1, a SET domain–containing histone methyltransferase, to the MLLT10 gene. The MLLT10 gene encodes a 1,027-amino acid protein with an N-terminal zinc finger and a C-terminal leucine zipper domain.
MLLT10 can also rearrange with the CALM gene in t(10;11)(p12;q14) translocations, producing chimeric fusion proteins MLL/AF10 and CALM/AF10, both retaining the leucine zipper motif of MLLT10. This motif interacts with GAS41, which in turn binds INI1, a component of the SWI/SNF chromatin remodeling complex.
Retention of the leucine zipper in these fusions suggests their potential role in disrupting normal gene regulation via chromatin remodeling interference.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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