Thermo Fisher Scientific Anthrax Lethal Factor Polyclonal Antibody
Anthrax lethal factor에 특이적인 rabbit polyclonal antibody로 Western blot에 적합. 비결합형 액상 형태이며 whole serum/PBS buffer로 제공. 세균 유래 항원에 반응하며 연구용으로만 사용.
- 판매단위
- pk
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Thermo Fisher Scientific Anthrax Lethal Factor Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Bacteria |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 47–65 of Anthrax lethal factor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage buffer | Whole serum/PBS with 0.2% gelatin |
| Contains | 0.05% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_1070412 |
Product Specific Information
Suggested positive control: recombinant protein.
Target Information
Anthrax infection is initiated by inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF).
PA binds to two related proteins on the cell surface—tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2). After PA binding, it is cleaved by a furin-like protease, and the bound fragment interacts with LF and EF. The resulting complex is endocytosed, allowing LF and EF translocation into the cytoplasm.
LF acts as the primary toxin of anthrax and functions as a specific protease that cleaves members of the MAPKK family near their amino terminus, disrupting MAPK signaling and inducing apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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