Thermo Fisher Scientific Contactin 2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Positive test controls include: Mouse brain, Mouse spinal cord, Rat brain.
The target is usually found in the following locations: Cell membrane, GPI-anchor, Lipid-anchor.

Immunogen sequence:
EVKIRSYNRR GDGPESLTAL VYSAEEEPRV APTKVWAKGV SSSEMNVTWE PVQQDMNGIL LGYEIRYWKA GDKEAAADRV RTAGLDTSAR VSGLHPNTKY HVTVRAYNRA GTGPASPSAN ATTMKPPPRR PPGNISWTFS SSSLSIKWDP VVPFRNESAV TGYKMLYQND LHLTPTLHLT GKNWIEIPVP EDIGHALVQI RTTGPGGDGI PAEVHIVRNG GTSMMVEN

Target Information

Contactin 2 (CNTN2, transiently-expressed axonal glycoprotein, AXT, TAX, TAX1, TAG-1, axonin 1) is a neuronal cell adhesion molecule (CAM) that influences the formation of axon connections in the developing nervous system. It belongs to the immunoglobulin superfamily (IgSF) and contains a glycosylphosphatidylinositol-anchor, six immunoglobulin (Ig)-like and four fibronectin type III (FNIII)-like domains.

Contactin 2 is expressed predominantly during neural development on the cell membrane of axons in nerve fiber tracts to guide commissural axons. It binds with NgCAM in the same membrane (cis-binding).
Heterophilic (Contactin 2/NgCAM and Contactin 2/NrCAM) binding sites are localized to the first four Ig domains, while the homophilic (Contactin 2/Contactin 2) binding site is localized to the FNIII domain.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.