Thermo Fisher Scientific Unc18-2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested dilution: 1:500–1:2,000

ELISA

• Tested concentration: 1 µg/mL

Product Specifications

Product Specific Information

• Positive test controls: Mouse thymus, Rat fat
• Immunogen sequence:
  MAPSGLKAVV GEKILSGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI LAEGITIVED INKRREPIPS LEAIYLLSPT EKALIKDFQG TPTFTYKAAH IFFTDTCPEP LFSELGRSRL AKVVKTLKEI HLAFLPYEAQ VFSLDAPHST YNLYCPFRAE ERTRQLEVLA QQIATLCATL QEYPAIRYRK GPEDTAQLAH AVLAKLNAFK ADTPSLGEGP EKTRSQLLIM DRAADPVSPL LHELTFQAMA YDLLDIEQDT YRYETTGLSE AREKAVLLDE

Target Information

This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.