Thermo Fisher Scientific SCN9A Polyclonal Antibody
SCN9A 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합. Rabbit IgG 기반으로 제작되었으며, 1 mg/mL 농도의 액상 형태. -20°C에서 보관하며 연구용으로만 사용 가능.
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Thermo Fisher Scientific SCN9A Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within Human NaV17 aa 1–50 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_2854612 |
Product Specific Information
Positive Control: A549, HeLa, SH-SY5Y, human liver cancer tissue, mouse colon tissue.
Target Information
Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily share structural similarity with two short intracellular termini, two membrane-spanning segments, and a large extracellular loop containing a conserved cysteine-rich region.
There are three homologous isoforms of ENaC (alpha, beta, and gamma). ENaC expressed in kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. It mediates aldosterone-dependent sodium reabsorption in the distal nephron, thus regulating blood pressure. ENaC is regulated partly through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddle’s syndrome), while loss-of-function mutations in alpha- or beta-ENaC cause pseudohypoaldosteronism (PHA-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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