Thermo Fisher Scientific CLIP170 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CLIP170 protein. Validated for WB, IHC, IHC(P), and IP applications. Recommended dilution range 1:500–1:10,000. Liquid form, 1 mg/mL concentration, stored at 4°C. Suitable for research use only.
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Thermo Fisher Scientific CLIP170 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1388 and 1438 of human Cytoplasmic Linker Protein 170 Alpha-2 (CLIP1, UniProt ID: P30622-3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
CLIP170 was initially identified as a novel intermediate filament-associated protein highly expressed in Reed-Sternberg cells, diagnostic for Hodgkin's disease. It localizes to microtubule plus ends and is required for endocytic vesicle binding. CLIP170 interacts with LIS1 to regulate dynein/dynactin binding to microtubules and may influence lamellipodia formation and cell invasion by modulating the release of kinesin and IQGAP1 from complexes involving CLIP170 and Rac1. At least two isoforms of CLIP170 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: A303-345A-M_CLIP1_P30622-3_Rabbit.svg)
(이미지: A303-345A-M_CLIP1_P30622-3_Rabbit_PDP.jpeg)
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