Thermo Fisher Scientific Human TNIP3 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 17 amino acids near the carboxy terminus of human ABIN3.
PEP-0912 can be used as a blocking peptide with polyclonal antibody PA5-20798.

Target Information

The nuclear factor NF-kappa-B plays key roles in development and immunity.
ABIN3 (A20-binding inhibitor of NF-kappa-B activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a novel negative feedback regulator of LPS-induced NF-kappa-B activation.
ABIN3 is a 39 kDa protein that negatively regulates NF-kappa-B activation in response to TNF and LPS. It is highly expressed in brain, thymus, lymph node, lung, and fetal liver, with low expression in kidney and bone marrow.

Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals, and NF-kappa-B inhibition is mediated by the ABIN-homology domain 2.
ABIN3 is induced by Listeria infection and can be slightly downregulated by dexamethasone.
Enhanced expression of ABIN3 in monocytes is associated with sepsis.
ABIN3 is an IL-10-induced gene product capable of attenuating NF-kappa-B in human macrophages yet is inoperative in mice, representing species-specific differences in IL-10 actions.
At least four isoforms of ABIN3 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.