Thermo Fisher Scientific ABHD3 Polyclonal Antibody

Applications

Product Specifications

Target Information

The α/β hydrolase superfamily comprises diverse members involved in important biochemical processes and various diseases. Despite differing sequences and substrates, they share a canonical α/β hydrolase fold with an eight-stranded parallel α/β structure and a catalytic triad (histidine, acid, nucleophile). Members of this superfamily are often drug targets for diseases such as diabetes, Alzheimer’s disease, obesity, and blood clotting disorders.

The α/β hydrolase domain containing (ABHD) gene subfamily includes 15 mostly uncharacterized members, most of which utilize a serine nucleophile to form the G-X-S-X-G nucleophile elbow.

• ABHD1 plays a role in metabolizing smoking xenobiotics.
• ABHD2 participates in the development of atherosclerosis.
• ABHD3 is a 409 amino acid single-pass type II membrane protein.
• ABHD4 is involved in an alternative synthesis pathway of NAE (N-acyl ethanolamine).
• ABHD5 mutations contribute to Chanarin-Dorfman syndrome.
• ABDH6 may play a role in nervous system metabolism and signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.