Thermo Fisher Scientific GPR17 Polyclonal Antibody
GPR17 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, ICC, ELISA 등에 사용 가능. 인간 시료 반응성. Protein A 정제 및 1 mg/mL 농도의 액상 형태로 제공. 신경계 연구 및 수초화 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry / Immunofluorescence (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human G protein coupled receptor 17 (amino acids 2–100) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The G-protein-coupled receptor (GPCR) superfamily comprises an estimated 600–1,000 members, representing the largest known class of molecular targets with proven therapeutic value.
GPR17 is an orphan G protein-coupled receptor involved in the orchestration of oligodendrocyte differentiation and myelination in the central nervous system.
It is expressed in brain, kidney, heart, and umbilical vein endothelial cells.
GPR17 has dual specificity for uracil nucleotides and cysteinyl leukotrienes, signaling through G(i) and inhibition of adenylyl cyclase.
It may mediate brain damage by nucleotides and cysteinyl leukotrienes following ischemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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