Thermo Fisher Scientific IRAK2 Monoclonal Antibody (OTI4C1), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

IRAK2 (interleukin-1 receptor-associated kinase-like 2) binds to the IL-1 type I receptor after IL-1 engagement and initiates intracellular signaling cascades that lead to transcriptional up-regulation and mRNA stabilization.
IL-1 induces a cellular response through two receptor subunits, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP).
IRAK family members, including IRAK2, mediate NF-κB activation, which is crucial for inflammatory and immune responses.
IRAK2 is expressed in various human tissues and plays a central role in IL-1R and Toll-like receptor (TLR)-mediated signaling pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.