Thermo Fisher Scientific IRAK2 Monoclonal Antibody (OTI4C1), TrueMAB
Human IRAK2 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot과 IHC(Paraffin)에 최적화되어 있습니다. 동결건조 형태로 제공되며, 고순도의 친화 크로마토그래피 정제 제품입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4C1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 362–625 of human IRAK2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
IRAK2 (interleukin-1 receptor-associated kinase-like 2) binds to the IL-1 type I receptor after IL-1 engagement and initiates intracellular signaling cascades that lead to transcriptional up-regulation and mRNA stabilization.
IL-1 induces a cellular response through two receptor subunits, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP).
IRAK family members, including IRAK2, mediate NF-κB activation, which is crucial for inflammatory and immune responses.
IRAK2 is expressed in various human tissues and plays a central role in IL-1R and Toll-like receptor (TLR)-mediated signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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