Thermo Fisher Scientific Phospho-PI3K p85/p55 (Tyr458, Tyr199) Polyclonal Antibody
PI3K p85/p55 단백질의 인산화 형태(Tyr458, Tyr199)를 인식하는 Rabbit Polyclonal Antibody. WB, IP, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 시약으로, -20°C 보관. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 8 publications |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Immunoprecipitation (IP) | 1:50 | View publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr458 of mouse p85 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 190 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10985894 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Phosphoinositide 3-kinase (PI3K, phospho PI3K) binds to activated (phosphorylated) protein-Tyr kinases through its SH2 domain and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
Phospho PI3K is necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. During insulin stimulation, it binds to IRS-1. Growth factors and hormones trigger this phosphorylation event, coordinating cell growth, cell cycle entry, cell migration, and cell survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-17387_PI3K_p85p55_O08908-1_Rabbit.svg, PA5-17387_PI3K_p85p55_O08908-1_Rabbit_PDP.jpeg)
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