Thermo Fisher Scientific BCL10 Monoclonal Antibody (OTI6A8), TrueMAB
BCL10 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot과 IHC(P)에서 검증됨. Human 및 Dog 시료에 반응. 동결건조 형태로 제공되며, PBS 완충액(8% trehalose) 기반. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6A8 |
| Immunogen | Full length human recombinant protein of human BCL10 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
BCL-10 is a CARD (Caspase Recruitment Domain) containing protein involved in the adaptive immune response.
It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-κB via NIK and IKK.
BCL-10 acts as an adapter between the upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex.
It is also a substrate for MALT1. Mutations in the BCL10 gene can lead to Immunodeficiency 37 or mucosa-associated lymphoid type lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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