Thermo Fisher Scientific SARM Recombinant Rabbit Monoclonal Antibody (HL1066)

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Store as a concentrated solution.
• Centrifuge briefly prior to opening vial.
• For short-term storage (1–2 weeks), store at 4°C.
• For long-term storage, aliquot and store at -20°C or below.
• Avoid multiple freeze–thaw cycles.

Target Information

SARM1은 손상 후 축삭 변성(axonal degeneration)을 조절하는 NAD(+) 가수분해 효소로, NAD(+) 대사를 조절하여 신경세포 사멸 및 면역 반응을 조절합니다.
Wallerian degeneration을 유도하며, MYD88 및 TRIF 의존적 Toll-like receptor 신호전달을 억제합니다.
또한 MAPK4-JNK 경로를 통해 수상돌기 가지화(dendritic arborization)를 조절합니다.
[UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.