Thermo Fisher Scientific MAVS Monoclonal Antibody (OTI8A11), TrueMAB
인간 MAVS 단백질(aa 1-247)을 항원으로 제작된 mouse IgG1 단클론 항체. Western blot 및 IHC(P)에서 사용 가능. 액상 형태, 1 mg/mL 농도, PBS/BSA/glycerol buffer 구성. 바이러스 감염 관련 면역 신호 연구용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8A11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–247 of human MAVS produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Two distinct signaling pathways activate host innate immunity against viral infection. One pathway relies on Toll-like receptor (TLR) family members, while the other uses RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA.
MAVS is a mitochondrial membrane protein crucial for IFN-beta signaling, recruiting IRF-3 to RIG-I and activating NF-kappa-B.
MAVS interacts with innate immune components such as TRIF, TRAF2, TRAF6, and IKK kinases (IKK-alpha, IKK-beta, IKK-iota).
Cleavage of MAVS by Hepatitis C virus protease allows viral immune evasion. Multiple isoforms of MAVS are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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