Thermo Fisher Scientific MAVS Monoclonal Antibody (OTI9C7), TrueMAB
인간 MAVS 단백질(aa 1-247)을 항원으로 한 Mouse IgG3 단일클론 항체. Western blot에 적합하며, 세포 내 바이러스 감염 관련 선천면역 연구용. 1 mg/mL 농도의 액상 형태로, -20°C에서 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG3 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9C7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–247 of human MAVS produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family, while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response.
MAVS is a mitochondrial membrane protein identified as a critical component in the IFN beta signaling pathway that recruits IRF-3 to RIG-I, leading to activation of NF-kappa-B. MAVS interacts with other innate immune components such as TRIF, TRAF2, and TRAF6, and with IKK-alpha, IKK-beta, and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to evade the host immune system. Multiple isoforms of MAVS are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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