Thermo Fisher Scientific PD-L2 (PDCD1LG2) Monoclonal Antibody (OTI5A7), TrueMAB
PD-L2 (PDCD1LG2) 단백질을 인식하는 Mouse Monoclonal Antibody (Clone OTI5A7). IHC(P) 및 Flow Cytometry에 사용 가능. Human 시료 반응성, Affinity chromatography로 정제된 1 mg/mL 액상 항체. PBS/BSA/glycerol buffer에 보관, -20°C 저장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | Assay-Dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5A7 |
| Immunogen | Full length human recombinant protein of human PDCD1LG2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Programmed death-ligand 2 (PD-L2), also known as B7-DC, is part of the B7 ligand family within the immunoglobulin superfamily. Along with PD-L1, it binds to PD-1, functioning as an inhibitory immune checkpoint molecule that regulates immune responses. PD-L2 is primarily expressed in dendritic cells but can be induced in various immune and non-immune cells depending on the microenvironment. Its expression is upregulated by cytokines such as IL-4, TNF-alpha, and IFN-gamma. PD-L2 has a higher binding affinity to PD-1 compared to PD-L1 and can modulate T cell activation and cytokine production. Additionally, PD-L2 interacts with RGMb, influencing respiratory tolerance and immune regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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