Thermo Fisher Scientific Phospho-Androgen Receptor (Ser94) Polyclonal Antibody
인간 Androgen Receptor Ser94 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, IHC(P), IHC(F), ICC/IF 등 다양한 형광 및 조직 염색에 사용 가능. 고순도 Protein A 정제, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용.
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Thermo Fisher Scientific Phospho-Androgen Receptor (Ser94) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human Androgen Receptor around the phosphorylation site of Ser94 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors.
It is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT).
Upon hormone binding, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and stimulates transcription of androgen-responsive genes.
AR signaling plays a key role in the development and function of male reproductive organs such as the prostate and epididymis, and also in non-reproductive organs including muscle, hair follicles, and brain.
The receptor is a phosphoprotein that regulates MAP kinase activity, and alterations in its phosphorylation state are linked to MEK1/2 pathway inhibition.
Abnormalities in AR signaling are associated with diseases such as prostate cancer, Kennedy’s disease, and male infertility.
Mutations in the AR gene can lead to complete androgen insensitivity (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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