Thermo Fisher Scientific Chk1 Polyclonal Antibody

Thermo Fisher Scientific Chk1 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:1,000–1:10,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Positive Control: human Chk1-transfected 293T.
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network. It functions to ensure genomic integrity upon genotoxic stress.
When the G2 or S checkpoint is abrogated by inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and apoptosis, whereas normal cells remain arrested in the G1 phase.
Thus, CHK1 inhibitors can enhance the efficacy of DNA-damaging agents in cancer cells, making Chk1 an attractive therapeutic target, especially since approximately 50% of all human cancers are p53-deficient.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.