Thermo Fisher Scientific Chk1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Chk1 for Western blot applications. Recognizes serine/threonine kinase involved in DNA damage response. Supplied as a liquid at 1 mg/mL concentration. Suitable for research use only.
- 판매단위
- pk
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Thermo Fisher Scientific Chk1 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:1,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human Chk1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792717 |
Product Specific Information
- Keep as concentrated solution.
- Positive Control: human Chk1-transfected 293T.
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network. It functions to ensure genomic integrity upon genotoxic stress.
When the G2 or S checkpoint is abrogated by inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and apoptosis, whereas normal cells remain arrested in the G1 phase.
Thus, CHK1 inhibitors can enhance the efficacy of DNA-damaging agents in cancer cells, making Chk1 an attractive therapeutic target, especially since approximately 50% of all human cancers are p53-deficient.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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