Thermo Fisher Scientific MST1-2/STK3-4 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human MST1/MST2 (STK3/STK4); validated for IHC and IHC-P; antigen affinity purified; supplied as liquid in TBS buffer with BSA and sodium azide; suitable for multiple species cross-reactivity prediction.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | C-terminus between residues 450–491 of human Mammalian Sterile 20-like 2 (Serine/Threonine Kinase 3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4 °C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Mouse, Rat, Zebrafish, X. laevis, X. tropicalis, Turkey, Bovine, Horse, Rabbit, Guinea pig, Panda, Orangutan, and Monkey
Target Information
STK3 and STK4 are stress-activated, pro-apoptotic kinases that, following caspase cleavage, translocate to the nucleus and induce chromatin condensation and DNA fragmentation. They are core components of the Hippo signaling pathway, which regulates organ size and tumor suppression by controlling cell proliferation and apoptosis.
STK3/MST2 and STK4/MST1, in complex with SAV1, activate LATS1/2, which phosphorylate and inactivate YAP1 and WWTR1/TAZ, thereby preventing nuclear translocation and gene activation related to proliferation and migration.
These kinases are essential for repressing hepatocyte proliferation, preventing liver stem cell activation, and inhibiting tumor formation. They phosphorylate NKX2-1, NEK2, CROCC, CEP250, MOBKL1A/B, RASSF2, and regulate RAF1 activation and ESR1 transcriptional activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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