Thermo Fisher Scientific GP1BA Monoclonal Antibody (2E5)
인간 GP1BA 단백질을 인식하는 마우스 단클론 항체로, ELISA에 적합합니다. CD42b 표적 연구에 사용되며, 혈소판 응집 및 응고 관련 연구에 유용합니다. PBS 용액 형태로 제공되며, -20°C에서 보관합니다.
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Applications
- ELISA (ELISA)
Tested Dilution: 3 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E5 |
| Immunogen | GP1BA (AAH27955, 19–128 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
ICEVSKVASH LEVNCDKRNL TALPPDLPKD TTILHLSENL LYTFSLATLM PYTRLTQLNL DRCELTKLQV DGTLPVLGTL DLSHNQLQSL PLLGQTLPAL TVLDVPFNRL
Target Information
CD42b is a platelet activation marker involved in coagulation as an aggregating factor. It interacts with extracellular matrix and adhesion molecules. CD42b expression and activation are regulated by VEGF and PDGF. Together with GPIb beta, GPIX, and GPV, CD42b forms the GPIb-IX-V receptor complex, which is essential for platelet-rich thrombus formation by tethering platelets to thrombogenic surfaces.
CD42b binds to von Willebrand factor (VWF), thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1, and P-selectin. The extracellular domain contributes to metastasis through these interactions.
CD42b antigen is expressed on platelets and megakaryocytes in bone marrow. Several polymorphisms and mutations in CD42b are associated with Bernard-Soulier syndromes and platelet-type von Willebrand disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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