Thermo Fisher Scientific CD8 Monoclonal Antibody (4B11)
인간 CD8 항원 인식용 Mouse Monoclonal Antibody (Clone 4B11). IHC(P) 및 IHC(F)에서 사용 가능하며, Tris/EDTA 열 항원 회복 권장. Unconjugated 형태, 4°C 보관, 인체 면역세포 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 12 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:50 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4B11 |
| Immunogen | Synthetic peptide derived from the carboxy terminal region of the human CD8 alpha chain (amino acids 223–235), coupled to bovine serum albumin and keyhole limpet hemocyanin. Sequence: C-KSDGKPSLSARYV |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Tissue culture supernatant |
| Contains | <0.1% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Wet ice |
| RRID | AB_929437 |
Product Specific Information
- Heat-mediated antigen retrieval using Tris/EDTA (pH 8) is recommended for paraffin sections.
- Suggested positive control: Human tonsil.
- Mouse anti-Human CD8 antibody (clone 4B11) recognizes the human CD8 cell surface antigen (~32 kDa glycoprotein), expressed by cytotoxic/suppressor T cells and weakly by NK cells.
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family involved in signal transduction, T cell differentiation, and activation.
CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer (CD8α/CD8β) functioning as a co-receptor for MHC-I molecules, while CD4 acts as a co-receptor for MHC-II.
CD8α chain is essential for MHC-I binding and is also expressed on subsets of T cells, NK cells, monocytes, and dendritic cells as homodimers.
Binding of MHC-I/peptide complexes triggers recruitment of Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are crucial for pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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