Thermo Fisher Scientific Phospho-STAT5 alpha/beta (Ser725, Ser730) Polyclonal Antibody
STAT5 α/β 인산화(Ser725, Ser730) 부위를 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 세포 신호전달 및 전사활성 연구에 적합하며, 액상 형태로 -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human STAT5 around the phosphorylation site of Ser725/Ser730. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903056 |
Target Information
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases, and then form homo- or heterodimers that translocate to the nucleus to act as transcription activators.
This protein mediates responses to ligands such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and various growth hormones.
Activation in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and essential for tumorigenesis.
The mouse counterpart induces expression of BCL2L1/BCL-X(L), suggesting an antiapoptotic function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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