Thermo Fisher Scientific Integrin beta 3 Polyclonal Antibody
인간 Integrin beta 3(CD61)에 특이적인 토끼 폴리클로날 항체로, Western blot, IHC, Flow cytometry, ELISA, IP에 활용 가능. 고순도 친화 크로마토그래피 정제, 액상 형태, -20°C 보관. 세포 부착 및 신호전달 연구에 적합.
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Thermo Fisher Scientific Integrin beta 3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | 1:100–1:200 |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | 5.0 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a C-terminal portion of human Integrin beta 3 conjugated to Keyhole Limpet Hemocyanin (KLH). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
This affinity-purified antibody is directed against human Integrin beta 3. Blast analysis of the sequence of the immunogen shows 100% identity with human and mouse.
Target Information
CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets, and their precursors. It plays a role in platelet aggregation and functions as a receptor for fibrinogen, fibronectin, von Willebrand factor, and vitronectin. CD61 (105 kDa) associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) at the cell surface.
CD61 is expressed on platelets and megakaryocytes (with CD41), and on endothelial cells, monocytes, and osteoclasts (with CD51). It participates in cell adhesion and cell-surface mediated signaling. Diseases associated with CD61 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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