Thermo Fisher Scientific POT1 Polyclonal Antibody
인간 POT1 단백질을 인식하는 Rabbit Polyclonal 항체로, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태이며, PBS와 40% 글리세롤 버퍼에 보관. 단기 4°C, 장기 -20°C 저장 권장.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human POT1. Recombinant protein control fragment (Product #RP-105452) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664935 |
Product Specific Information
Immunogen sequence:
LTFEGTLGAPI IPRTSSKYFN FTTEDHKMVE ALRVWASTHM SPSWTLLKLC DVQPMQYFDL TCQLLGKAEV DGASFLLKVW DGTR
Highest antigen sequence identity to the following orthologs:
- Mouse: 76%
- Rat: 74%
Target Information
POT1 is a component of the telomerase ribonucleoprotein (RNP) complex essential for replication of chromosome termini. It is part of the double-stranded telomeric DNA-binding TRF1 complex, regulating telomere length via cis-inhibition of telomerase. POT1 also acts as a single-stranded telomeric DNA-binding protein, potentially transducing telomere maintenance signals to the terminus. It binds specifically to telomeric single-stranded 5'-TTAGGG-3' repeats and the minimal sequence 5'-TAGGGTTAG-3'. Its activity is TERT-dependent but does not increase TERT activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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